Publications | Digital Health

Moynihan R, Sanders S, Michaleff ZA, Scott A, Clark J, To EJ, Jones M, Kitchener E, Fox M, Johansson M, Lang E, Duggan A, Scott I, Albarqouni L. Pandemic impacts on healthcare utilisation: a systematic review. medRxiv. 2020:2020.10.26.20219352.

Publications2020, COVID-19, healthcare services, pandemic

Objectives: To determine the extent and nature of changes in utilisation of healthcare services during COVID-19 pandemic. Design: Systematic review. Eligibility: Eligible studies compared utilisation of services during COVID-19 pandemic to at least one comparable period in prior years. Services included visits, admissions, diagnostics, and therapeutics. Studies were excluded if from single-centres or studied only

Byambasuren O, Dobler CC, Bell K, Rojas DP, Clark J, McLaws M-L, Glasziou P. Comparison of seroprevalence of SARS-CoV-2 infections with cumulative and imputed COVID-19 cases: systematic review. medRxiv. 2020:2020.07.13.20153163. preprint

Publications2020, COVID-19, SARS-CoV-2, seroprevalence, systematic review

Background. Accurate seroprevalence estimates of SARS-CoV-2 in different populations could clarify the extent to which current testing strategies are identifying all active infection, and hence the true magnitude and spread of the infection. Our primary objective was to identify valid seroprevalence studies of SARS-CoV-2 infection and compare their estimates with the reported and imputed COVID-19

Byambasuren O, Cardona M, Bell K, Clark J, McLaws M-L, Glasziou P. Estimating the extent of asymptomatic COVID-19 and its potential for community transmission: systematic review and meta-analysis. medRxiv. 2020:2020.05.10.20097543.

Publications2020, asymptomatic COVID-19, meta-analysis, SARS-CoV-2, systematic review

Background: The prevalence of true asymptomatic COVID-19 cases is critical to policy makers considering the effectiveness of mitigation measures against the SARS-CoV-2 pandemic. We aimed to synthesize all available research on the asymptomatic rates and transmission rates where possible. Methods: We searched PubMed, Embase, Cochrane COVID-19 trials, and Europe PMC (which covers pre-print platforms such

Bakhit M, Krzyzaniak N, Scott AM, Clark J, Glasziou P, Del Mar C. Downsides of face masks and possible mitigation strategies: a systematic review and meta-analysis. medRxiv. 2020:2020.06.16.20133207.

Publications2020, face masks, meta-analysis, systematic review

Objective To identify, appraise, and synthesise studies evaluating the downsides of wearing facemasks in any setting. We also discuss potential strategies to mitigate these downsides. Methods PubMed, Embase, CENTRAL, EuropePMC were searched (inception-18/5/2020), and clinical registries were searched via CENTRAL. We also did forward-backward citation search of the included studies. We included randomised controlled trials

Albarqouni L, Byambasuren, O., Clark, J., Scott, A.M., Looke, DGlasziou, P. Does Copper treating of commonly touched surfaces reduce healthcare acquired infections? A Systematic Review and meta-analysis. Journal of Hospital Infection. (106/4) p765-773, 2020

Publications2020, 2wSR, copper, copper linen, copper plating, healthcare-acquired infections, healthcare-associated infections, hospital-acquired infections

Background Healthcare-acquired infections (HAIs) cause substantial morbidity and mortality. Copper appears to have strong antimicrobial properties under laboratory conditions. Aim To examine the potential effect of copper treatment of commonly touched surfaces in healthcare facilities. Methods Controlled trials comparing the effect of copper-treated surfaces (furniture or bed linens) in hospital rooms compared with standard rooms

Scott AM, Clark J, Del Mar C, Glasziou P, Increased fluid intake to prevent urinary tract infections: systematic review and meta-analysis. British Journal of General Practice, 70(692), pp.e200-e207.

Publications2019, antibacterial agents, drinking, drug resistance, fluid therapy, microbial, systematic review, urinary tract infections

Background Approximately 15% of community-prescribed antibiotics are used in treating urinary tract infections (UTIs). Increase in antibiotic resistance necessitates considering alternatives. Aim To assess the impact of increased fluid intake in individuals at risk for UTIs, for impact on UTI recurrence (primary outcome), antimicrobial use, and UTI symptoms (secondary outcomes). Design and setting A systematic

Akhtyamova L, Martínez P, Verspoor K, Cardiff J. (2020) Testing Contextualized Word Embeddings to Improve NER in Spanish Clinical Case Narratives. IEEE Access.

Publications2020, big data, decision making, electronic health record, HER, Named Entity Recognition, natural language processing, NER, NLP

In the Big Data era, there is an increasing need to fully exploit and analyze the huge quantity of information available about health. Natural Language Processing (NLP) technologies can contribute by extracting relevant information from unstructured data contained in Electronic Health Records (EHR) such as clinical notes, patients’ discharge summaries and radiology reports. The extracted

Wilson DJ, and The CRyPTIC Consortium. GenomeMap: Within-species genome-wide dn/ds estimation from over 10,000 genomes. Molecular Biology and Evolution 2020;37(8):2450-2460.

Publications2020, adaptation, big data, dN/dS, natural selection, parent-dependent mutation, recombination

The dN/dS ratio provides evidence of adaptation or functional constraint in protein-coding genes by quantifying the relative excess or deficit of amino acid-replacing versus silent nucleotide variation. Inexpensive sequencing promises a better understanding of parameters, such as dN/dS, but analyzing very large data sets poses a major statistical challenge. Here, I introduce genomegaMap for estimating

Staccini P, Lau AYS; Social Media, Research, and Ethics: Does Participant Willingness Matter?. Section Editors for the IMIA Yearbook Section on Consumer Health Informatics and Education. Yearb Med Inform. 2020 Aug;29(1):176-183. doi: 10.1055/s-0040-1702022. Epub 2020 Aug 21.

Publications2020, bibliometrics, ethics, patient selection, privacy, research design, social media

Objective : To summarise the state of the art published in 2019 in consumer health informatics and education, with a special emphasis on “Ethics and Health Informatics”. Methods : We conducted a systematic search of articles published in PubMed using a predefined set of queries, which identified 368 potential articles for review. These articles were

Sittig DF, Wright A, Coiera E, et al. Current challenges in health information technology-related patient safety. Health Informatics J 2020;26(1):181-89 doi: 10.1177/1460458218814893[published Online First: Epub Date]

Publications2020, electronic health records; healthcare policy; information and knowledge management; information technology design and development methodologies; organizational change and information technology

We identify and describe nine key, short-term, challenges to help healthcare organizations, health information technology developers, researchers, policymakers, and funders focus their efforts on health information technology-related patient safety. Categorized according to the stage of the health information technology lifecycle where they appear, these challenges relate to (1) developing models, methods, and tools to enable

Rockett RJ, Arnott A, Lam C, Sadsad R, Timms V, Gray K-A, Eden J-S, Chang S, Gall M, Draper J, Sim EM, Bachmann NL, Carter I, Basile K, Byun R, O’Sullivan MV, Chen SCA, Maddocks S, Sorrell TC, Dwyer DE, Holmes EC, Kok J, Prokopenko M, Sintchenko V. Revealing COVID-19 transmission in Australia by SARS-CoV-2 genome sequencing and agent-based modelling. Nature Medicine 2020; 26(9):1398-1404.

Publications2020, epidemiology, genetic testing, SARS-CoV-2, viral genetics, viral infection

In January 2020, a novel betacoronavirus (family Coronaviridae), named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified as the etiological agent of a cluster of pneumonia cases occurring in Wuhan City, Hubei Province, China1,2. The disease arising from SARS-CoV-2 infection, coronavirus disease 2019 (COVID-19), subsequently spread rapidly causing a worldwide pandemic. Here we examine

Pederson M, Verspoor K, Jenkinson M, Law M, Abbott DF, Jackson GD (2020). Artificial Intelligence for clinical decision support in neurology. Brain Communications.

Publications2020, artificial intelligence, augmented intelligence, clinical decision support, deep learning, diagnosis, ethics, neurology

Artificial intelligence is one of the most exciting methodological shifts in our era. It holds the potential to transform healthcare as we know it, to a system where humans and machines work together to provide better treatment for our patients. It is now clear that cutting edge artificial intelligence models in conjunction with high-quality clinical

Liaw ST, Liyanage H, Kuziemsky C, Terry AL, Schreiber R, Jonnagaddala J, de Lusignan S. Ethical Use of Electronic Health Record Data and Artificial Intelligence: Recommendations of the Primary Care Informatics Working Group of the International Medical Informatics Association. Yearbook of Medical Informatics: Apr 2020

Publications2020, AI, artificial intelligence, ethical use of health data, ethics

Objective: To create practical recommendations for the curation of routinely collected health data and artificial intelligence (AI) in primary care with a focus on ensuring their ethical use. Methods: We defined data curation as the process of management of data throughout its lifecycle to ensure it can be used into the future. We used a

Jonnagaddala J, Guo GN, Batongbacal S, Marcelo A, Liaw ST. Adoption of enterprise architecture for healthcare in AeHIN member countries. BMJ Health & Care Informatics 2020; 27: e100136. DOI: 10.1136/bmjhci-2020-100136

Publications2020, AeHIN member countries, EA for healthcare, enterprise architecture for healthcare

Background Healthcare organisations are undergoing a major transformational shift in the use of information and digital health technologies. Enterprise architecture (EA) has been incrementally adopted in many healthcare organisations globally to facilitate this change. EA can increase the effectiveness of an organisation’s digital health capabilities and resources. However, little is known about the status of

Godinho MA, Jonnagaddala J, Gudi N, Islam R, Narasimhan P, Liaw ST. mHealth for Integrated People-Centred Health Services in the Western Pacific: A Systematic Review. Int J Med Informatics 2020; 142: 104259. DOI: https://doi.org/10.1016/j.ijmedinf.2020.104259.

Publications2020, mHealthmobile healthdigital healtheHealthintegrated careprimary careperson-centred care

Objective This review aimed to examine how mobile health (mHealth) to support integrated people-centred health services has been implemented and evaluated in the World Health Organization (WHO) Western Pacific Region (WPR). Methods Eight scientific databases were searched. Two independent reviewers screened the literature in title and abstract stages, followed by full-text appraisal, data extraction, and