Wilson DJ, and The CRyPTIC Consortium. GenomeMap: Within-species genome-wide dn/ds estimation from over 10,000 genomes. Molecular Biology and Evolution 2020;37(8):2450-2460.
The dN/dS ratio provides evidence of adaptation or functional constraint in protein-coding genes by quantifying the relative excess or deficit of amino acid-replacing versus silent nucleotide variation. Inexpensive sequencing promises a better understanding of parameters, such as dN/dS, but analyzing very large data sets poses a major statistical challenge. Here, I introduce genomegaMap for estimating