Albarqouni L, Moynihan R, Clark J, Scott AM, Duggan A, Del Mar C. Head of bed elevation to relieve gastroesophageal reflux symptoms: a systematic review. BMC Fam Pract. 2021 Jan 19;22(1):24. doi: 10.1186/s12875-021-01369-0. PMID: 33468060; PMCID: PMC7816499.

Background: Overuse of proton pump inhibitors (PPIs) – frequently used for relieving symptoms of gastroesophageal reflux disease (GORD) – raises long-term safety concerns, warranting evidence-based non-drug interventions. We conducted a systematic review to evaluate the effect of head-of-bed elevation on relieving symptoms of GORD in adults. Methods: We included controlled trials comparing the effect of

Scott AM, Clark J, Mar CD, Glasziou P. Increased fluid intake to prevent urinary tract infections: systematic review and meta-analysis. Br J Gen Pract. 2020 Feb 27;70(692):e200-e207. doi: 10.3399/bjgp20X708125. PMID: 31988085; PMCID: PMC6988703.

Background: Approximately 15% of community-prescribed antibiotics are used in treating urinary tract infections (UTIs). Increase in antibiotic resistance necessitates considering alternatives. Aim: To assess the impact of increased fluid intake in individuals at risk for UTIs, for impact on UTI recurrence (primary outcome), antimicrobial use, and UTI symptoms (secondary outcomes). Design and setting: A systematic

The Systemic Review Accelerator

How to complete a full Systematic Review in 2 weeks rather than 1 year  Before every great breakthrough there’s a dream or a vision. And one of the dreams of Chief Investigator Professor Paul Glasziou was to undertake systematic reviews in 2-weeks. Why, you might ask? Traditionally, systematic reviews have taken, on average, 67 weeks

Clark, J., Scott, A.M. and Glasziou, P., 2020. Not All Systematic Reviews Can Be Completed in 2 Weeks-But Many Can Be (And Should Be). Journal of Clinical Epidemiology, pp.S0895-4356.

Dear Editors, We would like to thank Yan et al. for providing us with an opportunity to expand on the applicability of our 2-week systematic review (2weekSR) processes [1]. Yan et al. correctly point out that “it is important to recognize not all systematic reviews (SRs) are created equal and complexity of the [SR] topic